Our laboratory studies how stem cells are regulated in the intestine and we use “mini gut” organoid cultures to study intestinal diseases and bowel cancer

Gastrointestinal polyps and cancer, treatment of coeliac disease and inflammatory bowel disease

Advocacy for colorectal cancer patients

The Wnt/B-catenin pathway in development and disease

Genomics and therapies for rare ovarian cancer subtypes

Advanced and recurrent pelvic malignancy, peritoneal disease, and minimally invasive and robotic surgery

Genetics and the prevention of bowel cancer

Pancreatic cancer, pancreatitis and colorectal liver metastases

Colorectal cancer genomics and response to therapy

Gastroenterology tumourigenesis, synthetic biology, mouse models and cancer prevention

Molecular control of colon stem cells and their relationship with cancer development

Signalling pathways in colorectal cancer and biomarker development

Understanding normal renewal of the lining of the bowel and stomach and how this is disrupted in the formation of tumours

Identifying new targets and developing therapies for solid tumour malignancies

Brain cancer, glioblastoma and tumour microenvironment

Cellular signalling in colorectal cancer metastasis and recurrence

Epigenetic Therapy, Differentiation Therapy, Discovery of Biomarkers to targeted Therapy

Gastrointestinal, colon and pancreatic cancers

Wnt signalling in gastrointestinal tissue homeostasis and cancer; adult tissue restricted-stem cell derived organoids to model infectious disease; cancers with viral infection aetiology

Genomics and cell biology of gastric cancer and early gastric lesions

Biomarker discovery for early detection of colorectal cancer

Clinical research in colorectal surgery

Colorectal cancer clinical trials and biomarker discovery

Omic analysis of recalcitrant cancers, personalised therapies, and further cancer genome discovery

Pancreatic cancer organoids and genomics

Treatment of colorectal cancer, inflammatory bowel disease, diverticular disease and anorectal disease

Gastrointestinal epithelial homeostasis and colorectal cancer, including the role of the immune system in therapy response

Innate immunity and cancer cell biology